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Party chaperone definition12/26/2023 ![]() ![]() An angry mob forms and lifts up Pearl and SpongeBob, who think they are popular enough to be lifted as until the mob throws them out of the building. However, this results in many injuries and mass destruction. They begin doing a dance called " Doing the Sponge," which everyone else soon begins doing. This ultimately succeeds, and Pearl and SpongeBob join the prom dance. Pearl, feeling sorry for him, attempts to console him and restore his confidence. SpongeBob and Pearl doing the Sponge dance. SpongeBob, after having broken everything at the prom, runs into the ladies' restroom crying. However, SpongeBob's costume soon begins malfunctioning, resulting in disaster and severely embarrassing Pearl. On the night of the prom, things initially work well for SpongeBob and Pearl. Pearl does not want to be embarrassed by SpongeBob, and begs him to try his best to not do anything embarrassing.Īt home, using a magazine Gary provides as a guide, SpongeBob dresses up and uses extremely long and unstable artificial legs to make himself look "long, tan, and handsome" for Pearl. Ultimately, he offers to have SpongeBob accompany her. He then suggests she take Squidward or one of the restaurant's customers to the prom, but she continues crying, which causes the earthquake to become worse. Krabs offers to take her instead, but she starts crying, causing an earthquake. Krabs asks her what is wrong, and she explains that her apparently "long, tan, and handsome" prom date has just dumped her the day before the prom. Just then, Pearl runs in crying so profusely that her tears begin to literally flood the restaurant. For example, the accumulation of the misfolded proteins in the cell causes (ER) stress. Hsp 90 chaperones aids in the proper folding of the misfolded proteins in the ER, thereby, it helps to relieve ER stress and its related diseases.The episode begins at the Krusty Krab, with SpongeBob making a Krabby Patty in the kitchen. They have a positive influence on endoplasmic reticulum (ER) stress-related pathologies. They are termed as chemical chaperons that help to treat several metabolic disorders, such as obesity, type 2 diabetes, and atherosclerosis. These molecules inhibit the signaling pathways involved in the growth and proliferation of tumor cells. Hsp 90 is a type of chaperon which has various therapeutic importance. Both Hsp 70 and 60 have two different forms, where the first form is the binding form and the second form is the folding-active state. They have 14 different components with two rings, made up of seven rings. This quarantine mechanism helps to prevent the proteins from getting clumped with other linear polypeptide chains in the cytoplasm. Hsp 60, unlike Hsp 70, which is involved in the prevention of protein aggregation, their function is to isolate unfolded proteins. ![]() These Hsp70 proteins recognize the “extended region” with the hydrophobic region of the unfolded protein, and prevent the random aggregation. The hydrolysis of ATP occurring at the N terminal of the chaperon molecule helps in the opening and binding of the substrate to the C terminal. They are monomers with a C and an N domain the C terminal domain binds with the substrate protein, while the N terminal domain contains ATPase. Hsp70 acts as a catalyst in protein folding processes, such as misfolding and refolding of the aggregated proteins, assembling and folding of newly synthesized proteins. The name heat shock protein was first identified from a bacterium that is at high stressful states such as high pH, temperature, and hypoxic conditions. ![]() The exposure of the heat destabilizes the protein structure, so during such harsh conditions they need assistance to fold. Chaperone molecules are termed as "heat shock" proteins (HSPs), as they are formed in a large amount when the cells get exposed to heat. ![]()
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